NOCTURNAL HYPOXEMIA FULL

Keywords: obstructive sleep apnea, triglycerides, hypoxemia, cohort studies, men, visceral obesity

Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.

In analysis stratified by waist circumference ( 100cm), ODI (3%, unstandardized B: 0.027, 95% CI: 0.015– 0.040), AHI (0.023, 0.012– 0.033) and AHI REM (0.012, 0.001– 0.022) were positively associated with serum triglycerides in participants with a normal waist circumference (< 95cm).Ĭonclusion: Obstructive sleep apnea metrics were positively associated with serum triglyceride levels in men with a normal waist circumference. Similarly, sensitivity analysis excluding lipid lowering therapies showed no significant associations. Overall, no significant associations between OSA metrics and lipid measures were found. Results: In 753 participants with mean (SD) age of 60.8 (10.9) years and waist circumference: 99.3 (11.6) cm, the prevalence of OSA (AHI≥ 10) was 52.6%. Effect modification was examined through stratification by waist circumference groups. Sensitivity analyses examined the effect of lipid lowering therapies on reported estimates. Multivariable linear regression analyses assessed associations between lipids and continuous measures of nocturnal hypoxemia (oxygen desaturation index (3%) (ODI), apnea–hypopnea index (AHI), and rapid eye movement sleep apnea–hypopnea index (REM-AHI)), adjusted for chronic conditions, risk behavior and sociodemographic factors.

Triglycerides, high- (HDL), low-density lipoprotein (LDL), and total cholesterol were assessed on a fasting morning blood sample.

NOCTURNAL HYPOXEMIA FULL

Methods: Cross-sectional data from participants of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study (n=753) who underwent full in-home polysomnography (Embletta X100) was used. Objective: To determine the association of obstructive sleep apnea and nocturnal hypoxemia with serum lipid profiles in unselected community-dwelling men. Layla B Guscoth, 1 Sarah L Appleton, 2 Sean A Martin, 1 Robert J Adams, 2 Yohannes A Melaku, 2 Gary A Wittert 1ġFreemasons Centre for Male Health and Well-Being, South Australian Health and Medical Research Institute and Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, 5000, Australia 2Flinders Health and Medical Research Institute (Sleep Health, Formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Adelaide, South Australia, 5042, Australiaįlinders Health and Medical Research Institute (Sleep Health, formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Bedford Park, Adelaide, South Australia, 5042, Australia

Nocturnal hypoxemia